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It was the best of times it was the worst of times. It was the age of wisdom, it was the age of foolishness. It was the spring of hope, it was the winter of despair.

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2020

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List projects

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List team members

Anand Alur Radhakrishnan Former msc student

Aitor Cortazar Former msc student

Berend Koele Former msc student

Christian Boerkamp Former msc student

Cecilia Molnar Former msc student

Chenyan Zhang PhD Student

Chunyan Xue Former msc student

Dario van Wagensveld Former msc student

Diogo Dias PhD Student

Django Brunink Former msc student

Eduardo Morejon Former msc student

Eshani Sarkar PhD Student

Francesc Varkevisser Former phd student

Flavia Valente Former msc student

Gandhika Wardhana Postdoctoral Researcher

Hassan Rivandi Former phd student

Hidde Woerdman Former msc student

Ines de los Mozos Vargas Former msc student

Ignas Dilevicius Former msc student

Ignasi Simon Grau PhD Student

Ishaan Ghosh Former msc student

Joost Berkelbach van der Sprenkel Former msc student

Jiaqi Pan MSc Student

Masoumeh Aqamolaei PhD Student

Niels Burghoorn Former msc student

Niels van Damme Former msc student

Niels van Lith Former msc student

Patrícia Rodrigues Former msc student

Peng Guo Former postdoc

Rajvi Lawande Former msc student

Reka Savundranayagam Former msc student

Samuel Desmarais PhD Student

Shuang Wang Former msc student

Tiago L. Costa Principal Investigator

Tom Wemelsfelder Former msc student

Xiaohua Huang Postdoctoral Researcher

Xinyu Yang Former msc student

Yidi Xiao Former msc student

Yihao Zhang Former msc student

Zeyao Huang Former msc student

List blog posts

2025

PhD graduation of Francesc Varkevisser

tlcosta October 02, 2025

team-updates

Francesc (Cesc) Varkevisser has succesfully defended his PhD, on September 25th! His thesis is entitled: Energy Efficiency Optimization in Large-scale Multichannel Electrical Neuromodulation. Cesc will continue his career in medical device company ADCORPUS in Barcelona, as a R&D Engineer. Good luck, Cesc!

Welcome Jiaqi Pan, new MSc student!

tlcosta October 01, 2025

team-updates

Welcome Jiai, the new MSc student in the MITUS lab! Jiaqi did her Bachelor (Electrical Engineering) and Master (Microelectronics) in TU Delft, and will work on microfabrication of acoustic holograms in her MSc thesis project.

Lab attended IEEE IUS 2025

tlcosta September 24, 2025

conferences

Our lab was present at the latest IEEE International Ultrasonics Symposium (IEEE IUS) in Utrecht, The Netherlands, with one oral presentation and 4 posters. Our recent MSc graduate Anand Radhakrishnan won the best student pitch competition award!

PhD graduation of Gandhika Wardhana!

tlcosta March 24, 2025 October 02, 2025

team-updates

Gandhika (Gandhi) Wardhana has succesfully defended his PhD! His thesis is entitled: Microtechnology for In-vitro Ultrasound Neuromodulation Studies. Gandhika will remain in the MITUS lab as a Postdoctoral researchers.

2024

PhD graduation of Hassan Rivandi!

tlcosta December 09, 2024 October 02, 2025

team-updates

Hassan Rivandi has succesfully defended his PhD! His thesis is entitled: CMOS Integrated Circuits to Interface with a 2D Array of Ultrasound Transducers for Ultrasound Brain Stimulation. Hassan will remain in the MITUS lab as a Postdoctoral researchers.

2022

EIC Pathfinder Open grant awarded

tlcosta May 04, 2022 October 01, 2025

funding

The MITUS lab is part of the consortium of the newly funded EIC Pathfinder project RELIEVE!

EIC Pathfinder Challenges grant awarded

tlcosta March 28, 2022 October 01, 2025

funding

The MITUS lab will coordinate a newly funded EIC Pathfinder Challenges project UPSIDE!

2021

HFSP reearch grant - early career

tlcosta April 01, 2021 October 01, 2025

funding

The MITUS lab got its first major grant: the Human Frontiers Science Program (HFSP) Research grant - Early career. Together with Andreas Hartel (Columbia University) and Wojciech Kopec (Max Planck Institute for Biophysical Chemistry), we will work on an interdisciplinary approach to unravel the fundamental mechanisms of focused ultrasound neuromodulation.

2019

MITUS lab launched at TU Delft!

tlcosta October 01, 2019 October 01, 2025

team-updates

The MITUS lab is starting in the Bioelectronics section - Microelectronics department at TU Delft! The lab will be working on integrated circuits and microfabrication for the next generation of ultrasound therapeutic implantable and wearable devices.

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Code

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Grid of citations

2025

A Programmable-Gain Floating Inverter Low-Noise Amplifier for Ultrasound Imaging Analog Frontends

Diogo Dias, Tiago Costa, João Goes

2025 IEEE International Symposium on Circuits and Systems (ISCAS)  ·  25 May 2025  ·  doi:10.1109/ISCAS56072.2025.11043193

Piezoelectric ion gated organic electrochemical transistors for efficient vibration sensing and on-site amplification

Linta Sohail, Sofia Drakopoulou, Tiago L. Costa, George D. Spyropoulos

npj Flexible Electronics  ·  08 May 2025  ·  doi:10.1038/s41528-025-00418-3

A Single-Inductor-Based High-Voltage Transmit Beamformer for Wearable Ultrasound Devices Achieving 88% fCV² Power Reduction

Peng Guo, Zu-Yao Chang, Michiel A. P. Pertijs, Tiago L. Costa

2025 IEEE International Solid-State Circuits Conference (ISSCC)  ·  16 Feb 2025  ·  doi:10.1109/ISSCC49661.2025.10904513

2024

Anti-reflective Microengineered Substrate for in vitro Ultrasound Neuromodulation

Gandhika K. Wardhana, Tiago L. Costa, Massimo Mastrangeli

2024 IEEE Ultrasonics, Ferroelectrics, and Frequency Control Joint Symposium (UFFC-JS)  ·  22 Sep 2024  ·  doi:10.1109/UFFC-JS60046.2024.10793577

2D Phased Array Driving Scheme Optimization for Ultrasound Neuromodulation

Masoumeh Aqamolaei, Tiago L. Costa

2024 IEEE Ultrasonics, Ferroelectrics, and Frequency Control Joint Symposium (UFFC-JS)  ·  22 Sep 2024  ·  doi:10.1109/UFFC-JS60046.2024.10793494

Feasibility Study for a High-Frequency Flexible Ultrasonic Cuff for High-Precision Vagus Nerve Ultrasound Neuromodulation

Cornelis van Damme, Gandhika K. Wardhana, Andrada Iulia Velea, Vasiliki Giagka, Tiago L. Costa

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control  ·  01 Jul 2024  ·  doi:10.1109/TUFFC.2024.3381923

A PVT-Robust Open-loop Gm-Ratio ×16 Gain Residue Amplifier for >1 GS/s Pipelined ADCs

Diogo Dias, João Goes, Tiago Costa

2024 IEEE International Symposium on Circuits and Systems (ISCAS)  ·  19 May 2024  ·  doi:10.1109/ISCAS58744.2024.10558154

An Acoustically Transparent Electrical Cap for Piezoelectric Ultrasound Transducers on Silicon

Gandhika K. Wardhana, Tiago L. Costa, Massimo Mastrangeli

Eurosensors 2023  ·  19 Mar 2024  ·  doi:10.3390/proceedings2024097050

PMUT and CMUT Devices for Biomedical Applications: A Review

Elisabetta Moisello, Lara Novaresi, Eshani Sarkar, Piero Malcovati, Tiago L. Costa, Edoardo Bonizzoni

IEEE Access  ·  01 Jan 2024  ·  doi:10.1109/ACCESS.2024.3359906

2023

Multichannel current-mode stimulator with channel-specific regulated power supply

Francesc Varkevisser, Tiago L. Costa, Wouter A. Serdijn

2023 IEEE Biomedical Circuits and Systems Conference (BioCAS)  ·  19 Oct 2023  ·  doi:10.1109/BioCAS58349.2023.10388577

An Energy-Efficient High-Voltage Pulser for High-Frequency Ultrasound Medical Applications

Yidi Xiao, Hassan Rivandi, Tiago L. Costa

2023 IEEE Biomedical Circuits and Systems Conference (BioCAS)  ·  19 Oct 2023  ·  doi:10.1109/BioCAS58349.2023.10388859

Hybrid neuroelectronics: towards a solution-centric way of thinking about complex problems in neurostimulation tools

Sofia Drakopoulou, Francesc Varkevisser, Linta Sohail, Masoumeh Aqamolaei, Tiago L. Costa, George D. Spyropoulos

Frontiers in Electronics  ·  12 Sep 2023  ·  doi:10.3389/felec.2023.1250655

A 2D Ultrasound Phased-Array Transmitter ASIC for High-Frequency US Stimulation and Powering

Hassan Rivandi, Tiago L. Costa

IEEE Transactions on Biomedical Circuits and Systems  ·  01 Aug 2023  ·  doi:10.1109/TBCAS.2023.3288891

2022

Pre-Filtering of Stimuli for Improved Energy Efficiency in Electrical Neural Stimulation

Francesc Varkevisser, Amin Rashidi, Tiago L. Costa, Vasiliki Giagka, Wouter A. Serdijn

2022 IEEE Biomedical Circuits and Systems Conference (BioCAS)  ·  13 Oct 2022  ·  doi:10.1109/BioCAS54905.2022.9948643

A High-Frequency Beamforming Channel for Ultrasound Stimulation and Ultrasonic Powering

Hassan Rivandi, Ishaan Ghosh, Tiago L. Costa

2022 IEEE Biomedical Circuits and Systems Conference (BioCAS)  ·  13 Oct 2022  ·  doi:10.1109/BioCAS54905.2022.9948550

Maximization of Transmitted Acoustic Intensity from Silicon Integrated Piezoelectric Ultrasound Transducers

Gandhika K. Wardhana, Massimo Mastrangeli, Tiago L. Costa

2022 IEEE International Ultrasonics Symposium (IUS)  ·  10 Oct 2022  ·  doi:10.1109/IUS54386.2022.9957646

Energy efficiency of pulse shaping in electrical stimulation: the interdependence of biophysical effects and circuit design losses

Francesc Varkevisser, Tiago L Costa, Wouter A Serdijn

Biomedical Physics & Engineering Express  ·  13 Sep 2022  ·  doi:10.1088/2057-1976/ac8c47

Design of a Flexible Transducer Array and Characterisation of Piezoelectric Sensors for Curvature Compensation

Christiaan Boerkamp, Tiago L. Costa, Jovana Jovanova

ASME 2022 Conference on Smart Materials, Adaptive Structures and Intelligent Systems  ·  12 Sep 2022  ·  doi:10.1115/SMASIS2022-90707

Stent with Piezoelectric Transducers for High Spatial Resolution Ultrasound Neuromodulation- a Finite Element Analysis

Ignas Dilevicius, Wouter A. Serdijn, Tiago L. Costa

2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)  ·  11 Jul 2022  ·  doi:10.1109/EMBC48229.2022.9871956

A Parasitic Resistance Extraction Tool Leveraged by Image Processing

Diogo Dias, Joao Goes, Tiago Costa

2022 IEEE International Symposium on Circuits and Systems (ISCAS)  ·  28 May 2022  ·  doi:10.1109/ISCAS48785.2022.9937879

2021

An Integrated 2D Ultrasound Phased Array Transmitter in CMOS With Pixel Pitch-Matched Beamforming

Tiago Costa, Chen Shi, Kevin Tien, Jeffrey Elloian, Filipe A. Cardoso, Kenneth L. Shepard

IEEE Transactions on Biomedical Circuits and Systems  ·  01 Aug 2021  ·  doi:10.1109/TBCAS.2021.3096722

Application of a sub–0.1-mm ³ implantable mote for in vivo real-time wireless temperature sensing

Chen Shi, Victoria Andino-Pavlovsky, Stephen A. Lee, Tiago Costa, Jeffrey Elloian, Elisa E. Konofagou, Kenneth L. Shepard

Science Advances  ·  07 May 2021  ·  doi:10.1126/sciadv.abf6312

2020

A 0.065-mm³Monolithically-Integrated Ultrasonic Wireless Sensing Mote for Real-Time Physiological Temperature Monitoring

Chen Shi, Tiago Costa, Jeffrey Elloian, Yihan Zhang, Kenneth L. Shepard

IEEE Transactions on Biomedical Circuits and Systems  ·  01 Jun 2020  ·  doi:10.1109/TBCAS.2020.2971066

Ablation of piezoelectric polyvinylidene fluoride with a 193 nm excimer laser

Jeffrey Elloian, Jeffrey Sherman, Tiago Costa, Chen Shi, Kenneth Shepard

Journal of Vacuum Science & Technology A: Vacuum, Surfaces, and Films  ·  11 Mar 2020  ·  doi:10.1116/1.5142494

Bidirectional Bioelectronic Interfaces: System Design and Circuit Implications

Yan Liu, Alessandro Urso, Ronaldo Martins da Ponte, Tiago Costa, Virgilio Valente, Vasiliki Giagka, Wouter A. Serdijn, Timothy G. Constandinou, Timothy Denison

IEEE Solid-State Circuits Magazine  ·  01 Jan 2020  ·  doi:10.1109/MSSC.2020.2987506

2019

A CMOS 2D Transmit Beamformer With Integrated PZT Ultrasound Transducers For Neuromodulation

Tiago Costa, Chen Shi, Kevin Tien, Kenneth L. Shepard

2019 IEEE Custom Integrated Circuits Conference (CICC)  ·  01 Apr 2019  ·  doi:10.1109/CICC.2019.8780236

2018

Monolithic Integration of Micron-scale Piezoelectric Materials with CMOS for Biomedical Applications

C. Shi, T. Costa, J. Elloian, K. L. Shepard

2018 IEEE International Electron Devices Meeting (IEDM)  ·  01 Dec 2018  ·  doi:10.1109/IEDM.2018.8614632

2017

A CMOS Front-End With Integrated Magnetoresistive Sensors for Biomolecular Recognition Detection Applications

Tiago Costa, Filipe A. Cardoso, Jose Germano, Paulo P. Freitas, Moises S. Piedade

IEEE Transactions on Biomedical Circuits and Systems  ·  01 Oct 2017  ·  doi:10.1109/TBCAS.2017.2743685

2016

Design and optimization of a CMOS front-end for magnetoresistive sensor based biomolecular recognition detection

Tiago Costa, Jose Germano, Moises S. Piedade, Filipe A. Cardoso, Paulo P. Freitas

2016 IEEE International Symposium on Circuits and Systems (ISCAS)  ·  01 May 2016  ·  doi:10.1109/ISCAS.2016.7539189

Semi-Quantitative Method for Streptococci Magnetic Detection in Raw Milk

Carla Duarte, Tiago Costa, Carla Carneiro, Rita Soares, Andrei Jitariu, Susana Cardoso, Moisés Piedade, Ricardo Bexiga, Paulo Freitas

Biosensors  ·  27 Apr 2016  ·  doi:10.3390/bios6020019

2015

Live demonstration: A CMOS ASIC for precise reading of a Magnetoresistive sensor array for NDT

Diogo M. Caetano, Moises Piedade, Joao Graca, Jorge Fernandes, Luis Rosado, Tiago Costa

2015 IEEE International Symposium on Circuits and Systems (ISCAS)  ·  01 May 2015  ·  doi:10.1109/ISCAS.2015.7169039

2014

A Neuronal Signal Detector for Biologically Generated Magnetic Fields

Tiago Costa, Moises S. Piedade, Jose Germano, Jose Amaral, Paulo P. Freitas

IEEE Transactions on Instrumentation and Measurement  ·  01 May 2014  ·  doi:10.1109/TIM.2013.2296417

2013

Integration of TMR Sensors in Silicon Microneedles for Magnetic Measurements of Neurons

Jose Amaral, Vitor Pinto, Tiago Costa, Joao Gaspar, Ricardo Ferreira, Elvira Paz, Susana Cardoso, Paulo P. Freitas

IEEE Transactions on Magnetics  ·  01 Jul 2013  ·  doi:10.1109/TMAG.2013.2239274

CMOS instrumentation system for matrix-based magnetoresistive biosensors

Tiago Costa, Moises S. Piedade, Filipe A. Cardoso, Paulo P. Freitas

2013 IEEE International Instrumentation and Measurement Technology Conference (I2MTC)  ·  01 May 2013  ·  doi:10.1109/I2MTC.2013.6555626

An instrumentation system based on magnetoresistive sensors for neuronal signal detection

Tiago Costa, Moises S. Piedade, Jose Germano, Jose Amaral, Paulo P. Freitas

2013 IEEE International Instrumentation and Measurement Technology Conference (I2MTC)  ·  01 May 2013  ·  doi:10.1109/I2MTC.2013.6555579

Measuring brain activity with magnetoresistive sensors integrated in micromachined probe needles

José Amaral, João Gaspar, Vitor Pinto, Tiago Costa, Nuno Sousa, Susana Cardoso, Paulo Freitas

Applied Physics A  ·  26 Feb 2013  ·  doi:10.1007/s00339-013-7621-7

2012

Integration of Magnetoresistive Biochips on a CMOS Circuit

F. A. Cardoso, T. Costa, J. Germano, S. Cardoso, J. Borme, J. Gaspar, J. R. Fernandes, M. S. Piedade, P. P. Freitas

IEEE Transactions on Magnetics  ·  01 Nov 2012  ·  doi:10.1109/TMAG.2012.2198449

An ultra-low noise current source for magnetoresistive biosensors biasing

T. Costa, M. S. Piedade, M. Santos

2012 IEEE Biomedical Circuits and Systems Conference (BioCAS)  ·  01 Nov 2012  ·  doi:10.1109/BioCAS.2012.6418507

2011

A CMOS circuit for precise reading of matrix addressed magnetoresistive biosensors

Tiago Costa, Moises S. Piedade, Jorge R. Fernandes

2011 IEEE Biomedical Circuits and Systems Conference (BioCAS)  ·  01 Nov 2011  ·  doi:10.1109/BioCAS.2011.6107809

Grid of blog posts

2025

PhD graduation of Francesc Varkevisser

tlcosta October 02, 2025

team-updates

Francesc (Cesc) Varkevisser has succesfully defended his PhD, on September 25th! His thesis is entitled: Energy Efficiency Optimization in Large-scale Multichannel Electrical Neuromodulation. Cesc will continue his career in medical device company ADCORPUS in Barcelona, as a R&D Engineer. Good luck, Cesc!

Welcome Jiaqi Pan, new MSc student!

tlcosta October 01, 2025

team-updates

Welcome Jiai, the new MSc student in the MITUS lab! Jiaqi did her Bachelor (Electrical Engineering) and Master (Microelectronics) in TU Delft, and will work on microfabrication of acoustic holograms in her MSc thesis project.

Lab attended IEEE IUS 2025

tlcosta September 24, 2025

conferences

Our lab was present at the latest IEEE International Ultrasonics Symposium (IEEE IUS) in Utrecht, The Netherlands, with one oral presentation and 4 posters. Our recent MSc graduate Anand Radhakrishnan won the best student pitch competition award!

PhD graduation of Gandhika Wardhana!

tlcosta March 24, 2025 October 02, 2025

team-updates

Gandhika (Gandhi) Wardhana has succesfully defended his PhD! His thesis is entitled: Microtechnology for In-vitro Ultrasound Neuromodulation Studies. Gandhika will remain in the MITUS lab as a Postdoctoral researchers.

2024

PhD graduation of Hassan Rivandi!

tlcosta December 09, 2024 October 02, 2025

team-updates

Hassan Rivandi has succesfully defended his PhD! His thesis is entitled: CMOS Integrated Circuits to Interface with a 2D Array of Ultrasound Transducers for Ultrasound Brain Stimulation. Hassan will remain in the MITUS lab as a Postdoctoral researchers.

2022

EIC Pathfinder Open grant awarded

tlcosta May 04, 2022 October 01, 2025

funding

The MITUS lab is part of the consortium of the newly funded EIC Pathfinder project RELIEVE!

EIC Pathfinder Challenges grant awarded

tlcosta March 28, 2022 October 01, 2025

funding

The MITUS lab will coordinate a newly funded EIC Pathfinder Challenges project UPSIDE!

2021

HFSP reearch grant - early career

tlcosta April 01, 2021 October 01, 2025

funding

The MITUS lab got its first major grant: the Human Frontiers Science Program (HFSP) Research grant - Early career. Together with Andreas Hartel (Columbia University) and Wojciech Kopec (Max Planck Institute for Biophysical Chemistry), we will work on an interdisciplinary approach to unravel the fundamental mechanisms of focused ultrasound neuromodulation.

2019

MITUS lab launched at TU Delft!

tlcosta October 01, 2019 October 01, 2025

team-updates

The MITUS lab is starting in the Bioelectronics section - Microelectronics department at TU Delft! The lab will be working on integrated circuits and microfabrication for the next generation of ultrasound therapeutic implantable and wearable devices.

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